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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis

Figure 3

Vasoactive intestinal peptide (VIP) modulates the pattern of expression of the RANK/RANKL/OPG system in joints from mice with collagen-induced arthritis (CIA). (a) Expression of mRNA for receptor activator of nuclear factor-κB (RANK), receptor activator of nuclear factor-κB ligand (RANKL) or osteoprotegerin (OPG) in the hind paws was measured by quantitative real time PCR and corrected by mRNA expression for β-actin in each sample (see Materials and methods). (b) Serum levels of OPG in control, CIA or VIP-treated CIA mice were determined by ELISA. On day 10 of VIP treatment, differences between the arthritic group and the CIA group treated with VIP were statistically significant (**p < 0.01, ***p < 0.001). Results are the mean ± SEM of two independent experiments with 10 animals per group

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