Ā | Clinical score | Cartilage destruction | Bone erosion |
---|
CIA | 5.08 Ā± 0.24 | 2.8 Ā± 0.07 | 2.13 Ā± 0.12 |
CIA + VIP | 1.56 Ā± 0.17a | 0.61 Ā± 0.22a | 0.25 Ā± 0.11a |
- Clinical score (mean Ā± SEM) was assessed on a scale of 0 to 6. Cartilage destruction and bone erosion (mean Ā± SEM) was graded on a scale from 0 to 3. On day 10 of vasoactive intestinal peptide (VIP) treatment, differences between the arthritic group and the collagen-induced arthritis (CIA) group treated with VIP were statistically significant (ap < 0.001).