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Table 2 Effect of VIP treatment of mice with collagen-induced arthritis

From: Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis

Ā 

Clinical score

Cartilage destruction

Bone erosion

CIA

5.08 Ā± 0.24

2.8 Ā± 0.07

2.13 Ā± 0.12

CIA + VIP

1.56 Ā± 0.17a

0.61 Ā± 0.22a

0.25 Ā± 0.11a

  1. Clinical score (mean Ā± SEM) was assessed on a scale of 0 to 6. Cartilage destruction and bone erosion (mean Ā± SEM) was graded on a scale from 0 to 3. On day 10 of vasoactive intestinal peptide (VIP) treatment, differences between the arthritic group and the collagen-induced arthritis (CIA) group treated with VIP were statistically significant (ap < 0.001).