Ā | CIA | CIA + VIP |
---|
RANKL | 51.20 Ā± 3.57 | 13.08 Ā± 2.45a |
OPG | 1.46 Ā± 0.27 | 2.46 Ā± 0.92 |
RANKL/OPG | 35.09 Ā± 3.18 | 5.30 Ā± 0.95a |
- The mRNA expression for RANKL and OPG in hind paws of mice with collagen-induced arthritis (CIA) was measured by quantitative real time PCR and corrected by mRNA expression for Ī²-actin in each sample. On day 10 of vasoactive intestinal peptide (VIP) treatment, differences between the arthritic group and the CIA group treated with VIP were statistically significant (ap < 0.001). Results are the mean Ā± SEM of two independent experiments with 10 animals per group. OPG, osteoprotegerin; RANKL, receptor activator of nuclear factor-ĪŗB ligand.