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Table 3 Ratio of RANKL to OPG in mice with collagen-induced arthritis

From: Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis

  CIA CIA + VIP
RANKL 51.20 ± 3.57 13.08 ± 2.45a
OPG 1.46 ± 0.27 2.46 ± 0.92
RANKL/OPG 35.09 ± 3.18 5.30 ± 0.95a
  1. The mRNA expression for RANKL and OPG in hind paws of mice with collagen-induced arthritis (CIA) was measured by quantitative real time PCR and corrected by mRNA expression for β-actin in each sample. On day 10 of vasoactive intestinal peptide (VIP) treatment, differences between the arthritic group and the CIA group treated with VIP were statistically significant (ap < 0.001). Results are the mean ± SEM of two independent experiments with 10 animals per group. OPG, osteoprotegerin; RANKL, receptor activator of nuclear factor-κB ligand.