Figure 1From: ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritisSchematic representation of the minimal domain organisation of matrix metalloproteinase (MMP), ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs; for example ADAMTS-4) proteinases. Note that most MMPs possess additional C-terminal extensions containing domains such as hemopexin-like and fibronectin type II domains. ADAMTS possess from 0 to 14 additional thrombospondin type 1-like repeat (TSR)-like motifs C-terminal to the spacer domain. EGF, epidermal growth factor; TM, transmembrane.Back to article page