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Figure 1 | Arthritis Research & Therapy

Figure 1

From: ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis

Figure 1

Schematic representation of the minimal domain organisation of matrix metalloproteinase (MMP), ADAM (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs; for example ADAMTS-4) proteinases. Note that most MMPs possess additional C-terminal extensions containing domains such as hemopexin-like and fibronectin type II domains. ADAMTS possess from 0 to 14 additional thrombospondin type 1-like repeat (TSR)-like motifs C-terminal to the spacer domain. EGF, epidermal growth factor; TM, transmembrane.

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