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Figure 2 | Arthritis Research & Therapy

Figure 2

From: ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis

Figure 2

Schematic representation of the structural and evolutionary relationship of the 19 human ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene products. The dendrogram was calculated with ClustalW 1.7 [7]. The structural representation of ADAMTS proteins was adapted from [81]. Where applicable the long form of splice variants is shown (see the text). CS, chondroitin sulphate; CUB, complement C1r/C1s, Uegf (epidermal growth factor-related sea urchin protein) and BMP-1 (bone morphogenic protein-1); PLAC, protease and lacunin; TSR, thrombospondin I-like repeat; vWFCP, von Willebrand factor-cleaving protease.

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