Schematic representation of the structural and evolutionary relationship of the 19 human ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) gene products. The dendrogram was calculated with ClustalW 1.7 . The structural representation of ADAMTS proteins was adapted from . Where applicable the long form of splice variants is shown (see the text). CS, chondroitin sulphate; CUB, complement C1r/C1s, Uegf (epidermal growth factor-related sea urchin protein) and BMP-1 (bone morphogenic protein-1); PLAC, protease and lacunin; TSR, thrombospondin I-like repeat; vWFCP, von Willebrand factor-cleaving protease.