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Table 3 Induced hyperhemia in patients with systemic sclerosis or primary Raynaud's phenomenon and healthy controls

From: Local hyperhemia to heating is impaired in secondary Raynaud's phenomenon

  Healthy controls (n = 20) Primary RP (n = 20) SSc (n = 20) P-value
Amplitude of the thermal response (median cutaneous vascular conductance (mV/mm Hg), 10th-90th percentile)     
   Baseline 7.2 (1.1–38) 6.4 (1.4–26.3) 5.2 (1.2–25.9) NS
   10 min thermal peak 43.4 (23.2–63) 42.6 (31–80.7) 27 (14.7–51.4)a 0.01
   10–30 min thermal peak 35.5 (12.2–55) 37.2 (24.3–70.6) 24.7 (13.5–51) 0.09
   44°C thermal peak 43.1 (21.3–62.1) 42.6 (31.6–74.3) 25.4 (15–52.4)a 0.01
Kinetics of the thermal response (median time, seconds)     
   Time to first thermal peak 190 (125–230) 160 (91–311) 391 (171–1483)a 0.0001
   Time to second peak 1458 (867–1949) 1394 (967–1991) - NS
Amplitude of the response to sublingual nitroglycerin (median vascular conductance (mV/mm Hg), 10th-90th percentile)     
   Baseline 14.1 (1.1–54.2) 4.6 (0.8–32) 11.5 (1.4–38) NS
   4 min peak 16.5 (1.6–55) 9.1 (1.2–34.5) 16.8 (3.6–37.7) NS
Amplitude of the post-occlusive response (median cutaneous vascular conductance (mV/mm Hg), 10th-90th percentile)     
   Baseline conductance 13 (1.3–49) 4.8 (1.1–32) 7.7 (1.4–30) NS
   Peak hyperhemic conductance 36.8 (11–65) 28.5 (9.3–49) 25.1 (9.5–50.2)b 0.05
Kinetics of the post-occlusive response (median time (seconds) 10th-90th percentile)     
   Time to peak hyperhemia 34.3 (17.4–76.5) 44.4 (19.8–104) 108.5 (15–287)a 0.003
   Duration of hyperhemia 165 (75–277) 150 (97–345) 225 (82–345) NS
  1. Data are medians, with 10th and 90th percentiles in parentheses. Cutaneous blood flow is expressed as cutaneous conductance (mV/mm Hg). Local heating at 42°C was applied for 30 minutes, followed by 5 minutes heating at 44°C. The cutaneous blood conductance was measured on the left middle fingerpad. aP < 0.05 following Bonferroni's correction versus healthy controls and versus primary Raynaud's phenomenon (RP), Mann-Whitney test. bP < 0.05 following Bonferroni's correction versus healthy controls. SSc, systemic sclerosis.