Skip to main content

Table 2 Variance component analysis of FS1-OA variation in Chuvashian pedigrees

From: Association of ENPP1gene polymorphisms with hand osteoarthritis in a Chuvasha population

Parameter

Estimate ± SE

Regression coefficients

 

   Intercept

 

αm

0.0000a

αf

0.0633 ± 0.0294

   Age effect

 

β1m

0.0519 ± 0.0011

β1f

0.0519b

   Stature effect

 

β2m

[0]

β2f

[0]

   Body weight effect

 

β3m

[0]

β3f

[0]

Variance components

 

VAD

0.0654 ± 0.0208 (24.43%)

VSP

0.0355 ± 0.0176 (13.26%)

VHS

[0]

VSB

[0]

VRS

0.1668 ± 0.0219 (62.31%)

LRT c

 

χ2

9.88

df

7

P

0.84

  1. Parameter estimates and corresponding asymptotic standard errors (SEs) are provided for the best fitting and most parsimonious genetic model. [ ] Parameter was fixed at the indicated value. αm and αf are sex-specific intercepts (m, males; f, females). βm and βf are sex-specific slopes. aParameter estimate reached the boundary. bParameter was fixed to be equal to the previous. cLRT for comparison of the most parsimonious and general model where all parameters were estimated. df, degrees of freedom; FS1-OA, first factor score obtained from principal component analysis of OA; LRT, likelihood ratio test; V, variation, due to additive genetic effect (VAD) or to common environment shared by parents (VSP), by siblings (VSB), or by all members of nuclear pedigrees/household (VHS).