Allele

Freq.

P values of TDT

Combined P value for 3 tests^{a}

n inf.

Pedigree disequilibrium test


 
FBAT

QTDT^{b}

EOT

A

B
 
P

Δ (years)


10

0.13

0.0051

0.0054

0.0083

0.0001

0.0016

59

0.0151

2.6

10 + 11^{c}

0.15

0.0019

0.0015

0.0043

4.0e6

0.0004

63

0.0060

2.9

5 + 6^{c}

0.13

0.0622

0.0216

0.0490

0.0055

0.0181

49

0.1326

1.6

 The artificial 'allele' 4F combines all rare alleles but not the three most frequent alleles. ^{a}Combined P value using χ^{2} (A) and simulated threedimensional null distribution (B). ^{b}Column presents orthogonal test, which uses parent trait values as covariates. ^{c}Artificial alleles including pairs of adjacent alleles. Δ, mean difference between the allele carriers and other individuals in age at onset of the disorder; EOT = extreme offspring design ttest; FBAT, familybased association test; Freq., frequency; n inf., number of informative families for TDT in the sample; QTDT = quantitative transmission disequilibrium test; TDT = transmission disequilibrium test.