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Table 4 Reanalysis of M06NR1A 'allele' 4F

From: Association of ENPP1gene polymorphisms with hand osteoarthritis in a Chuvasha population

Allele Freq. P values of TDT Combined P value for 3 testsa n inf. Pedigree disequilibrium test
   FBAT QTDTb EOT A B   P Δ (years)
10 0.13 0.0051 0.0054 0.0083 0.0001 0.0016 59 0.0151 -2.6
10 + 11c 0.15 0.0019 0.0015 0.0043 4.0e-6 0.0004 63 0.0060 -2.9
5 + 6c 0.13 0.0622 0.0216 0.0490 0.0055 0.0181 49 0.1326 -1.6
  1. The artificial 'allele' 4F combines all rare alleles but not the three most frequent alleles. aCombined P value using χ2 (A) and simulated three-dimensional null distribution (B). bColumn presents orthogonal test, which uses parent trait values as covariates. cArtificial alleles including pairs of adjacent alleles. Δ, mean difference between the allele carriers and other individuals in age at onset of the disorder; EOT = extreme offspring design t-test; FBAT, family-based association test; Freq., frequency; n inf., number of informative families for TDT in the sample; QTDT = quantitative transmission disequilibrium test; TDT = transmission disequilibrium test.