Table 1 Classification of neutropenia

Congenital

Severe infantile agranulocytosis (Kostmann's syndrome)

Shwachman–Diamond–Oski syndrome

Myelokathexis/neutropenia with tetraploid nuclei

Cyclic neutropenia

Chediak–Higashi syndrome

Reticular dysgenesis

Dyskeratosis congenita

Acquired

Postinfectious neutropenia

Drug-induced neutropenia

Complement activation (haemodialysis, leukapheresis, ARDS)

Immune neutropenia

   Isoimmune neonatal neutropenia

   Alloimmune neutropenia (transfusion reaction)

   Autoimmune neutropenia – primary

Benign of childhood

Adult chronic form

   Autoimmune neutropenia – secondary

Autoimmune diseases

Large granular lymphocyte

Other (see Table 3)

   Pure white cell aplasia

Chronic idiopathic neutropenia

Hypersplenism

Nutritional deficiency (vitamin B₁₂ or folate deficiency)

Diseases affecting the bone marrow

   Postchemotherapy

   Aplastic anaemia

   Fanconi anaemia

   Myelodysplastic syndrome

   Acute and chronic leukaemia