Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis

Table 2 CXCL12 increases and AMD3100 inhibits osteoclast activity

	Number of pits with indicated resorption area^a
In vitro stimulation^b	50–100 μm²	100–500 μm²	500–1,000 μm²	1,000–5,000 μm²	>5,000 μm²
Control	481	1,002	166	153	22
CXCL12	848	1,854	382	346	90
CXCL12 + AMD3100	598	1,143	193	164	5
AMD3100	580	1,008	171	140	6

^aThe table shows the number of osteoclast resorption pits for five different surface intervals. ^bSplenocytes of collagen type II/complete Freund's adjuvant-immunized mice were cultured as described in the legend of Fig. 8, and the resorbed area was measured.

ISSN: 1478-6362