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Table 3 Doppler echocardiographic studies in patients with RA

From: Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis

Reference Publication year No. of RA patients No. of control subjects Findings (RA compared to control)
Mustonen et al. [86] 1993 12 (males; age 20–40 years) 14 (males only; unmatched) LV diastolic functional impairment
No differences in LV systolic function
Corrao et al. [88] 1996 40 40 non-RA Increased interventricular septal thickness
Increased LV mass index
LV diastolic functional impairment
Wislowska et al. [89] 1998 100 100 non-RA Increased LV diastolic diameter Reduced
LV ejection fraction
Montecucco et al. [90] 1999 54 54 non-RA Impaired diastolic relaxation
No differences in LV systolic function or LV diastolic diameter
Wislowska et al. [91] 1999 35 with nodular RA 35 with non-nodular RA Increased valvular disease in nodular RA
Decreased LV ejection fraction in nodular RA
Di Franco et al. [92] 2000 32 33 non-RA (unmatched) LV diastolic functional impairment
Positive correlation with RA disease duration (r = 0.40)
Cindas et al. [87] 2002 40 48 non-RA LV diastolic functional impairment
Longer disease duration with more abnormal echocardiographic parameters noted
Alpaslan et al. [93] 2003 32 with long standing RA 32 non-RA (unmatched) LV diastolic functional impairment
Normal systolic function in all
Levendoglu et al. [94] 2003 40 - LV diastolic functional impairment
Positive correlation with RA disease duration
Gonzalez-Juanatey et al. [55] 2004 47 treated RA patients 47 LV diastolic functional impairment
Positive correlation with extra-articular manifestations of RA
  1. LV, left ventricular; RA, rheumatoid arthritis.