Genotype | n (%) | sTNF-RI (pg/ml) | sTNF-RII (pg/ml) |
|---|
Unstimulated T cells |
TT | 38 (65.5) | 166.8 ± 57.8 | 582.2 ± 259.6 |
TG | 15 (25.9) | 144.1 ± 78.2 | 428.1 ± 222.3 |
GG | 5 (8.6) | 137.2 ± 68.9 | 398.8 ± 194.9 |
Stimulated T cells |
TT | 38 (65.5) | 178.0 ± 57.9 | 998.3 ± 355.6 |
TG | 15 (25.9) | 146.5 ± 75.5 | 769.5 ± 292.8 |
GG | 5 (8.6) | 141.6 ± 75.7 | 724.4 ± 167.3 |
- Shown is the association between tumour necrosis factor receptor II (TNF-RII) T676G single nucleotide polymorphism genotype and soluble tumour necrosis factor (sTNFR) levels released by T cells isolated from rheumatoid arthritis (RA) patients (n = 58). sTNFR levels are expressed as mean ± standard deviation. Levels of sTNFR released into culture medium of isolated T cells exhibited a similar trend of decreasing levels of both receptors according to TNF-RII genotype (order: TT > TG > GG), although only the associations with sTNF-RII were significant (unstimulated and stimulated cells, respectively: P for trend = 0.049 and P for trend = 0.02; multiple regression analysis corrected for age, sex and disease duration). sTNF-RI, soluble tumor necrosis factor receptor I.
