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Table 4 Association between TNF-RII T676G single nucleotide polymorphism genotype and sTNFR levels released by T cells

From: Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis

Genotype n (%) sTNF-RI (pg/ml) sTNF-RII (pg/ml)
Unstimulated T cells
TT 38 (65.5) 166.8 ± 57.8 582.2 ± 259.6
TG 15 (25.9) 144.1 ± 78.2 428.1 ± 222.3
GG 5 (8.6) 137.2 ± 68.9 398.8 ± 194.9
Stimulated T cells
TT 38 (65.5) 178.0 ± 57.9 998.3 ± 355.6
TG 15 (25.9) 146.5 ± 75.5 769.5 ± 292.8
GG 5 (8.6) 141.6 ± 75.7 724.4 ± 167.3
  1. Shown is the association between tumour necrosis factor receptor II (TNF-RII) T676G single nucleotide polymorphism genotype and soluble tumour necrosis factor (sTNFR) levels released by T cells isolated from rheumatoid arthritis (RA) patients (n = 58). sTNFR levels are expressed as mean ± standard deviation. Levels of sTNFR released into culture medium of isolated T cells exhibited a similar trend of decreasing levels of both receptors according to TNF-RII genotype (order: TT > TG > GG), although only the associations with sTNF-RII were significant (unstimulated and stimulated cells, respectively: P for trend = 0.049 and P for trend = 0.02; multiple regression analysis corrected for age, sex and disease duration). sTNF-RI, soluble tumor necrosis factor receptor I.