Figure 4
From: Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase
Role of B cells in the pathology of G6PI-induced arthritis. The role of B cells in the pathology of glucose-6-phosphate isomerase (G6PI)-induced arthritis was addressed using B-cell deficient μMT mice on B10.Q and C3H.Q backgrounds. Mice aged between 6 and 7 weeks were immunized with 200 μg G6PI in complete Freund's adjuvant and scored for arthritis. (a) Five out of seven B10.Q mice developed arthritis, whereas none of the six B10.Q μMT mice exhibited signs of inflammation. (b) Four out of 12 C3H.Q μMT mice exhibited mild oedema for no longer than 48 hours, whereas all nine C3H.Q littermate control mice demonstrated a destructive inflammatory disease course. Error bars indicate the standard error of the mean.