Suppression of proliferative activity of RA FLS by DHMEQ. Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) were stimulated with tumor necrosis factor (TNF)-α or unstimulated in the presence or absence of dehydroxymethylepoxyquinomicin (DHMEQ), cultured for 48 hours, and incorporation of [3H]thymidine during the last 24 hours was measured. Values are expressed as mean ± standard deviation of triplicate measurements. Data shown are representative of three independent experiments. *P < 0.01, **P < 0.001. cpm, counts/minute.