Table 3 Multivariable analyses of differences between offspring and controls in changes in cartilage measures
From: Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study
Outcome factor | Univariable analysis | β and 95% confidence interval | |||||
|---|---|---|---|---|---|---|---|
| Â | Â | Cartilagea | Cartilagea and BMI | Knee pain | Bone sizeb | Other outcomec | All factors |
Differences in annual change in cartilage volume | |||||||
   Medial tibial (%) | -1.06 (-2.01,-0.10) | -0.77 (-1.61,+0.08) | -0.62 (-1.46,+0.23) | -0.89 (-1.88,+0.10) | -0.64 (-1.60,+0.31) | -0.71 (-1.57,+0.15) | -0.27 (-1.14,+0.60) |
   Lateral tibial (%) | -0.79 (-1.60,-0.00) | -0.55 (-1.32,+0.21) | -0.44 (-1.22,+0.33) | -0.55 (-1.43,+0.33) | -0.52 (-1.33,+0.29) | -0.75 (-1.59,+0.07) | -0.32 (-1.21,+0.56) |
   Patellar (%) | -0.98 (-1.83,-0.12) | -0.96 (-1.78,-0.15) | -0.74 (-1.56,+0.09) | -0.85 (-1.76,+0.06) | -1.01 (-1.87,-0.17) | -0.75 (-1.56,+0.06) | -0.55 (-1.37,+0.26) |
   Total (%) | -0.86 (-1.54,-0.17) | -0.71 (-1.33,-0.10) | -0.54 (-1.17,+0.09) | -0.69 (-1.40,+0.02) | -0.63 (-1.34,+0.07) | -0.60 (-1.23,+0.04) | -0.28 (-0.94,+0.38) |
Differences in annual change in cartilage defects | |||||||
   Medial (number) | 0.16 (0.00,0.32) | 0.22 (0.07,0.38) | 0.19 (0.05,0.34) | 0.13 (-0.04,+0.31) | 0.11 (-0.06,+0.27) | 0.09 (-0.05,+0.23) | 0.11 (-0.04,+0.26) |
   Patella (number) | 0.09 (-0.05,+0.24) | 0.14 (0.00,0.29) | 0.12 (-0.03,+0.26) | 0.09 (-0.06,+0.25) | 0.08 (-0.06,+0.23) | 0.05 (-0.09,+0.20) | 0.07 (-0.07,+0.22) |
   Total (number) | 0.26 (-0.06,+0.59) | 0.41 (0.06,0.76) | 0.32 (-0.01,+0.66) | 0.23 (-0.12,+0.59) | 0.16 (-0.17,+0.48) | 0.11 (-0.19,+0.40) | 0.19 (-0.13,+0.50) |