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Table 3 Multivariable analyses of differences between offspring and controls in changes in cartilage measures

From: Genetic mechanisms of knee osteoarthritis: a population-based longitudinal study

Outcome factor Univariable analysis β and 95% confidence interval
   Cartilagea Cartilagea and BMI Knee pain Bone sizeb Other outcomec All factors
Differences in annual change in cartilage volume
   Medial tibial (%) -1.06 (-2.01,-0.10) -0.77 (-1.61,+0.08) -0.62 (-1.46,+0.23) -0.89 (-1.88,+0.10) -0.64 (-1.60,+0.31) -0.71 (-1.57,+0.15) -0.27 (-1.14,+0.60)
   Lateral tibial (%) -0.79 (-1.60,-0.00) -0.55 (-1.32,+0.21) -0.44 (-1.22,+0.33) -0.55 (-1.43,+0.33) -0.52 (-1.33,+0.29) -0.75 (-1.59,+0.07) -0.32 (-1.21,+0.56)
   Patellar (%) -0.98 (-1.83,-0.12) -0.96 (-1.78,-0.15) -0.74 (-1.56,+0.09) -0.85 (-1.76,+0.06) -1.01 (-1.87,-0.17) -0.75 (-1.56,+0.06) -0.55 (-1.37,+0.26)
   Total (%) -0.86 (-1.54,-0.17) -0.71 (-1.33,-0.10) -0.54 (-1.17,+0.09) -0.69 (-1.40,+0.02) -0.63 (-1.34,+0.07) -0.60 (-1.23,+0.04) -0.28 (-0.94,+0.38)
Differences in annual change in cartilage defects
   Medial (number) 0.16 (0.00,0.32) 0.22 (0.07,0.38) 0.19 (0.05,0.34) 0.13 (-0.04,+0.31) 0.11 (-0.06,+0.27) 0.09 (-0.05,+0.23) 0.11 (-0.04,+0.26)
   Patella (number) 0.09 (-0.05,+0.24) 0.14 (0.00,0.29) 0.12 (-0.03,+0.26) 0.09 (-0.06,+0.25) 0.08 (-0.06,+0.23) 0.05 (-0.09,+0.20) 0.07 (-0.07,+0.22)
   Total (number) 0.26 (-0.06,+0.59) 0.41 (0.06,0.76) 0.32 (-0.01,+0.66) 0.23 (-0.12,+0.59) 0.16 (-0.17,+0.48) 0.11 (-0.19,+0.40) 0.19 (-0.13,+0.50)
  1. Bold denotes statistical significance. aAdjusted for differences at baseline in cartilage volume (analyses of differences in change in cartilage volume) or in cartilage defects (analyses of differences in change in cartilage defects); badjusted for differences at baseline in bone size at this site; cadjusted for differences at baseline in annual change in cartilage defects (analyses of differences in change in cartilage volume) or in annual change in cartilage volume (analyses of differences in change in cartilage defects).