Table 3 The effect of homozygosity for HLA-DRB1*04 shared epitope alleles on risk for severe ExRA manifestations
From: The impact of HLA-DRB1genes on extra-articular disease manifestations in rheumatoid arthritis
Manifestations | Homozygotes (yes/no; %) | OR (95% CI) | P | |
|---|---|---|---|---|
Cases with manifestation | Controls without manifestation | |||
All ExRA | 39/116 (25) | 28/149 (16) | 1.79 (1.04–3.08) | 0.04 |
Pericarditis | 8/19 (29) | 59/246 (19) | 1.76 (0.73–4.19) | 0.21 |
Felty's syndrome | 8/13 (38) | 59/252 (19) | 2.63 (1.04–6.63) | 0.04 |
Neuropathy | 8/32 (20) | 59/233 (20) | 0.99 (0.43–2.25) | 0.98 |
Interstitial lung disease | 3/22 (12) | 64/243 (21) | 0.52 (0.15–1.78) | 0.30 |
Vasculitis | 15/28 (35) | 52/237 (18) | 2.44 (1.22–4.89) | 0.01 |