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Table 3 The effect of homozygosity for HLA-DRB1*04 shared epitope alleles on risk for severe ExRA manifestations

From: The impact of HLA-DRB1genes on extra-articular disease manifestations in rheumatoid arthritis

Manifestations Homozygotes (yes/no; %) OR (95% CI) P
  Cases with manifestation Controls without manifestation   
All ExRA 39/116 (25) 28/149 (16) 1.79 (1.04–3.08) 0.04
Pericarditis 8/19 (29) 59/246 (19) 1.76 (0.73–4.19) 0.21
Felty's syndrome 8/13 (38) 59/252 (19) 2.63 (1.04–6.63) 0.04
Neuropathy 8/32 (20) 59/233 (20) 0.99 (0.43–2.25) 0.98
Interstitial lung disease 3/22 (12) 64/243 (21) 0.52 (0.15–1.78) 0.30
Vasculitis 15/28 (35) 52/237 (18) 2.44 (1.22–4.89) 0.01
  1. CI, confidence interval; ExRA, extra-articular rheumatoid arthritis; OR, odds ratio.