Figure 1

Nucleophosmin-binding activity of WB lupus-prone and control mouse sera. (a) Sera from male (◆) and female (■) WB mice, and from male CD1 (▴) mice, collected during months 1 to 2, 2 to 3, 3 to 4 and 4 to 6, were tested in solid-phase ELISA. The horizontal dotted line represents the cutoff value (mean A₄₀₅ of controls + 2 SD). Sera with A₄₀₅ < 0.522 were considered negative. (* P = 0.03, ** P = 0.01, *** P = 0.0001; Mann-Whitney test). (b) Different dilutions of male (◆) and female (■) WB and male (▴) CD1 mouse sera collected at 3.5 months were tested in ELISA.