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Table 1 Histological and biochemical characteristics of baseline values of human osteoarthritic cartilage for different treatment groups

From: Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitrostudy

Parameter Indomethacin (10 μmol/l) Naproxen (300 μmol/l) Aceclofenac (0.03 μmol/l) Celecoxib (0.01 μmol/l)
Age (years) 70 ± 2 67 ± 3 63 ± 2 70 ± 3
Sex (female/male) 4/1 3/2 4/1 4/1
Histological cartilage damage (Mankin grade) 3 ± 1 4 ± 1 6 ± 2 5 ± 2
Prostaglandin synthesis rate (nmol/hour per g) 6.8 ± 2.3 3.4 ± 1.9 4.8 ± 0.9 5.5 ± 1.8
% New prostaglandin release 11 ± 2 13 ± 2 12 ± 2 11 ± 2
% Total release 9 ± 2 7 ± 2 5 ± 1 6 ± 1
Prostaglandin content (mg/g) 22 ± 2 19 ± 1 17 ± 6 19 ± 1