Skip to main content

Table 4 Estimated pairwise haplotype frequencies in rheumatoid arthritis patients and healthy controls

From: Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B

Genes Haplotype UK Caucasian North Indian/Pakistani
   Control RA P a Nodular RA P Control RA P
FCGR2A-FCGR3A 131R-158F 0.43 0.41 0.25 0.32 0.13 0.34 0.30 0.46
  131R-158V 0.11 0.11   0.16   0.11 0.15  
  131H-158F 0.27 0.22   0.22   0.36 0.34  
  131H-158V 0.19 0.26   0.30   0.19 0.21  
FCGR3A-FCGR3B 158F-NA2 0.42 0.31 0.08 0.27 0.07 0.38 0.36 0.33
  158F-NA1 0.28 0.32   0.27   0.34 0.29  
  158V-NA2 0.24 0.31   0.37   0.19 0.25  
  158V-NA1 0.06 0.06   0.09   0.10 0.11  
FCGR3B-FCGR2B NA2-1206G 0.36 0.34 0.77 0.35 0.41 0.33 0.33 0.45
  NA2-1206A 0.29 0.27   0.30   0.24 0.28  
  NA1-1206G 0.31 0.33   0.26   0.37 0.37  
  NA1-1206A 0.04 0.06   0.09   0.06 0.03  
  1. Pairwise haplotypes produced from four biallelic markers (FCGR2A-131H/R, FCGR3A-158F/V, FCGR3B-NA2/1 and FCGR2B-1206G/A) denoted in the order they occur at the FCGR locus. Thus, 131R-158F indicates a haplotype containing FCGR2A-131R and FCGR3A-158F alleles. aEmpirical P values obtained from a heterogeneity test statistic incorporated in the PM program after 1,000 permutations. RA, rheumatoid arthritis.