Analysis of Fcγ receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B

Table 4 Estimated pairwise haplotype frequencies in rheumatoid arthritis patients and healthy controls

Genes	Haplotype	UK Caucasian					North Indian/Pakistani
		Control	RA	P ^a	Nodular RA	P	Control	RA	P
FCGR2A-FCGR3A	131R-158F	0.43	0.41	0.25	0.32	0.13	0.34	0.30	0.46
	131R-158V	0.11	0.11		0.16		0.11	0.15
	131H-158F	0.27	0.22		0.22		0.36	0.34
	131H-158V	0.19	0.26		0.30		0.19	0.21
FCGR3A-FCGR3B	158F-NA2	0.42	0.31	0.08	0.27	0.07	0.38	0.36	0.33
	158F-NA1	0.28	0.32		0.27		0.34	0.29
	158V-NA2	0.24	0.31		0.37		0.19	0.25
	158V-NA1	0.06	0.06		0.09		0.10	0.11
FCGR3B-FCGR2B	NA2-1206G	0.36	0.34	0.77	0.35	0.41	0.33	0.33	0.45
	NA2-1206A	0.29	0.27		0.30		0.24	0.28
	NA1-1206G	0.31	0.33		0.26		0.37	0.37
	NA1-1206A	0.04	0.06		0.09		0.06	0.03

Pairwise haplotypes produced from four biallelic markers (FCGR2A-131H/R, FCGR3A-158F/V, FCGR3B-NA2/1 and FCGR2B-1206G/A) denoted in the order they occur at the FCGR locus. Thus, 131R-158F indicates a haplotype containing FCGR2A-131R and FCGR3A-158F alleles. ^aEmpirical P values obtained from a heterogeneity test statistic incorporated in the PM program after 1,000 permutations. RA, rheumatoid arthritis.

ISSN: 1478-6362