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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

Figure 2

Relationship of dose of PEG-uricase and serum or plasma uric acid concentration. (a) Data for each dose cohort. (b) Data for two groups of subjects with distinct pharmacokinetic patterns: 'long-circulating' (plasma uricase activity (pUox) present three weeks after injection (n = 8)) and 'early elimination' (pUox undetectable beyond 10 days after injection (n = 5)). The horizontal axis indicates days after injection of PEG-modified recombinant mammalian urate oxidase (PEG-uricase); 'pre*', serum obtained at screening, just before the two-week allopurinol washout period; 'd 0', plasma obtained immediately before PEG-uricase injection.

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Arthritis Research & Therapy

ISSN: 1478-6362

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