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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

Figure 4

Time course of appearance of IgM and IgG antibodies against PEG-uricase, and of plasma uricase activity, in 'early elimination' subjects 002, 011, and 013. Subject 002 received 4 mg, and subjects 011 and 013 each received 12 mg, of PEG-modified recombinant mammalian urate oxidase (PEG-uricase).

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Arthritis Research & Therapy

ISSN: 1478-6362

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