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Table 1 Characteristics of subjects

From: Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase

Characteristic

Value (n = 13)

Sex (F/M)

3/10

Age (years)

 

   Overall

56.1 (40–75)

   Females

64.7 (63–66)

   Males

53.5 (40–75)

No. of subjects with tophi

11

No. of subjects on medication

 

   Allopurinol

6

   Uricosurics

0

   Colchicine

3

   Prednisone (for gout)

8

Serum uric acid (mg/dl)

 

   Overall

10.1 ± 2.3 (6.9–14.7)

   On allopurinol

10.0 ± 2.4 (6.9–14.7)

   Not on allopurinol

10.3 ± 2.3 (7.1–13.8)

Serum creatinine (mg/dl)

1.6 ± 0.5 (0.9–2.5)

No. of subjects with co-morbidity

 

   Osteoarthritis

3

   Hypertension

7

   Heart disease

2

   Diabetes

1

  1. Where errors are shown, results are means ± SD; numbers in parentheses are ranges. Serum uric acid and serum creatinine were measured before allopurinol washout.