Skip to main content

Advertisement

Table 3 Conditional logistic regression analyses of combinations of genes and antibodies

From: PTPN22polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease

Combination of variables Pre-patients Controls OR 95% CI
  n % n %   
PTPN22 CT+TT- + anti-CCP Abs- 39 45.3 272 78.4 1.00  
PTPN22 CT+TT+ + anti-CCP Abs- 15 17.5 70 20.2 1.20 0.62–2.35
PTPN22 CT+TT- + anti-CCP Abs+ 13 15.1 5 1.4 16.61 4.68–58.97
PTPN22 CT+TT+ + anti-CCP Abs+ 19 22.1 0a 0.0 132.03a 17.84–2720.91a
PTPN22 CT+TT- + IgG-RF- 27 48.2 175 76.1 1.00  
PTPN22 CT+TT+ + IgG-RF- 19 33.9 46 20.0 2.47 1.26–4.85
PTPN22 CT+TT- + IgG-RF+ 9 16.1 6 2.6 10.08 3.00–33.94
PTPN22 CT+TT+ + IgG-RF+ 1 1.8 3 1.3 1.50 0.15–14.84
PTPN22 CT+TT- + IgA-RF- 23 41.1 171 74.3 1.00  
PTPN22 CT+TT+ + IgA-RF- 11 19.6 47 20.4 1.55 0.69–3.49
PTPN22 CT+TT- + IgA-RF+ 13 23.2 10 4.4 9.23 3.31–25.76
PTPN22 CT+TT+ + IgA-RF+ 9 16.1 2 0.9 21.42 4.45–103.16
PTPN22 CT+TT- + IgM-RF- 28 50.0 170 73.9 1.00  
PTPN22 CT+TT+ + IgM-RF- 16 28.6 46 20.0 1.97 0.98–4.04
PTPN22 CT+TT- + IgM-RF+ 8 14.3 11 4.8 4.65 1.65–13.13
PTPN22 CT+TT+ + IgM-RF+ 4 7.1 3 1.3 10.70 1.78–64.23
PTPN22 CT+TT- + SE- 24 27.6 86 50.6 1.00  
PTPN22 CT+TT+ + SE- 14 16.1 18 10.6 3.35 1.34–8.26
PTPN22 CT+TT- + SE+ 28 32.2 54 31.8 2.12 1.06–4.25
PTPN22 CT+TT+ + SE+ 21 24.1 12 7.0 7.85 3.03–20.30
  1. Results of conditional logistic regression analyses of carriage of the PTPN22 1858T variant (CT + TT), HLA shared epitope (SE), anti-cyclic citrullinated peptide antibodies (anti-CCP Abs) or rheumatoid factors (RFs) of IgG, IgM, or IgA isotype for the prediction of rheumatoid arthritis in individuals who later developed the disease and matched controls. aCalculations made with a hypothetical control individual positive for both the PTPN22 1858T variant and anti-CCP antibodies.