Skip to main content

Advertisement

Table 2 Association between the VDR genotypes and hand osteoarthritis (OA)

From: Vitamin D receptor gene polymorphisms and susceptibility of hand osteoarthritis in Finnish women

Genotype Overall OA Symmetrical OA Osteophyte
  Yes/no Odds ratio (95% CI)a Yes/no Odds ratio (95% CI)a Yes/no Odds ratio (95% CI)a
ApaIb       
   AA 51/123 1.0 29/145 1.0 18/156 1.0
   Aa 77/191 0.98 (0.62–1.54) 56/212 1.43 (0.84–2.42) 14/254 0.46 (0.21–1.00)
   aa 32/69 1.20 (0.67–2.15) 25/76 1.93 (1.00–3.70) 7/94 0.65 (0.24–1.75)
   'A' allele carriage 128/303 0.82 (0.49–1.37) 85/357 0.65 (0.37–1.13) 32/410 1.01 (0.40–2.51)
   'a' allele carriage 109/260 1.03 (0.67–1.59) 81/288 1.55 (0.94–2.56) 21/348 0.51 (0.25–1.03)
TaqIc       
   tt 20/44 1.00 11/53 1.0 7/57 1.0
   Tt 68/173 0.75 (0.39–1.44) 42/199 0.90 (0.41–1.97) 13/228 0.46 (0.16–1.26)
   TT 71/164 0.92 (0.48–1.76) 57/178 1.53 (0.72–3.29) 19/216 0.73 (0.27–1.93)
   't' allele carriage 88/217 0.87 (0.58–1.30) 53/252 0.60 (0.38–0.94) 20/285 0.77 (0.39–1.53)
   'T' allele carriage 139/337 0.83 (0.45–1.54) 99/377 1.19 (0.57–2.47) 32/444 0.58 (0.23–1.46)
  1. aOdds ratio and 95% confidence interval (CI) adjusted for age (years), height (cm), occupation (1 = dentists, 2 = teachers [reference group]), hormone therapy (1 = ever used, 2 = never used [reference group]), current body mass index (1 = high, 2 = moderate, 3 = low [reference group]), daily calcium intake (1 = high [reference group], 2 = moderate, 3 = low), coffee consumption (number of cups per day), alcohol consumption (number of portion per week), and smoking history (1 = never smoked [reference group], 2 = ever smoked). bA, absence of a restriction site; a, presence of a restriction site. cT, absence of a restriction site; t, presence of a restriction site. For technical reasons, three samples were not genotyped for the TaqI VDR polymorphism.