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Table 1 Grading of kidney lesions

From: Therapeutic impact of the ethyl acetate extract of Tripterygium wilfordiiHook F on nephritis in NZB/W F1 mice

Score Glomerulonephritis Interstitial nephritis Vessels
1+ Focal, mild or early proliferative 1–3 small foci (5–10 cells) of MNC * MNC around renal pelvis/blood vessels
2+ Multifocal proliferative with increased matrix and inflammatory cells Mild MNC infiltrates around individual tubules; isolated atrophied tubules MNC infiltrates around main arteries; small foci 10–20 cells of MNC around interlobular arteries
3+ Diffuse proliferative More extensive infiltrates with large foci of tubular atrophy Individual foci of MNC around small arterial branches more extensive
4+ Extensive sclerosis/ crescents: proteinuria Extensive MNC infiltrates between tubules; extensive tubule atrophy/necrosis MNC infiltrates extend into surrounding parenchyma/most vessels affected/vasculitis
  1. *MNC = mononuclear cells.