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Table 1 Classification of inhibitory oligodeoxynucleotides

From: Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus

Feature Class B Class R
Cell specificity All TLR9+ cells MZ-B, DC, MF
Potency Nanomolar Nanomolar
Structure Linear–primary Secondary
Backbone PS PS or SOS
Effect on BCR signaling No Yes(?) in anti-dsDNA B cells
Inhibitory activity in animal lupus Yes [132] Yes [125]
Prototype
  1. BCR, B cell receptor for antigen; DC, dendritic cell; ds, double stranded; MF, macrophages; MZ, marginal zone; PS, phosphorothioate; SOS, chimeric – phosphorothioate-phosphodiester-phosphorothioate; TLR, Toll-like receptor.