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Table 1 Classification of inhibitory oligodeoxynucleotides

From: Targeting Toll-like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus

Feature

Class B

Class R

Cell specificity

All TLR9+ cells

MZ-B, DC, MF

Potency

Nanomolar

Nanomolar

Structure

Linear–primary

Secondary

Backbone

PS

PS or SOS

Effect on BCR signaling

No

Yes(?) in anti-dsDNA B cells

Inhibitory activity in animal lupus

Yes [132]

Yes [125]

Prototype

  1. BCR, B cell receptor for antigen; DC, dendritic cell; ds, double stranded; MF, macrophages; MZ, marginal zone; PS, phosphorothioate; SOS, chimeric – phosphorothioate-phosphodiester-phosphorothioate; TLR, Toll-like receptor.
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Arthritis Research & Therapy

ISSN: 1478-6362

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