|
Feature
|
Class B
|
Class R
|
|---|
|
Cell specificity
|
All TLR9+ cells
|
MZ-B, DC, MF
|
|
Potency
|
Nanomolar
|
Nanomolar
|
|
Structure
|
Linear–primary
|
Secondary
|
|
Backbone
|
PS
|
PS or SOS
|
|
Effect on BCR signaling
|
No
|
Yes(?) in anti-dsDNA B cells
|
|
Inhibitory activity in animal lupus
|
Yes [132]
|
Yes [125]
|
|
Prototype
|
|
|
- BCR, B cell receptor for antigen; DC, dendritic cell; ds, double stranded; MF, macrophages; MZ, marginal zone; PS, phosphorothioate; SOS, chimeric – phosphorothioate-phosphodiester-phosphorothioate; TLR, Toll-like receptor.
