Identification of collagen-induced arthritis loci in aged multiparous female mice

Table 1 Severity of arthritis and anti-collagen type II (anti-CII) titers in (NFR/N × B10.Q) × B10.Q female mice and parental strains

Generation	n	Day of onset (range)^a	Maximum score^b	Anti-CII titers (± standard error) (mg/ml) on day 100
F0 NFR/N	20	76.0 (11–102)	4.0 ± 1	1.53 ± 0.37^c
F0 B10.Q	19	49.5 (12–69)	4.0 ± 1	0.87 ± 0.11
(NFR/N × B10.Q) × B10.Q	200	56.0 (8–105)	6.0 ± 0.2	1.63 ± 0.18

^aMedian value on the days of onset when calculated in all arthritic mice in the group on day 100 (maximum–minimum values in the series).
^bMean ± standard error of the maximum score from all arthritic mice in the respective group.
^cSignificantly higher than in B10.Q mice (P = 0.02 in Student's unpaired t test).

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