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Table 2 Treatment terminations for ineffectiveness in original and re-employed methotrexate therapies

From: Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure

   Re-employed course Total
   No inefficacy Inefficacy  
Original course No inefficacy 19 (9.7 ± 3.1/11.4 ± 4.9) 9 (10.0 ± 4.0/15.8 ± 6.5) 28 (9.8 ± 3.3/12.9 ± 5.8)
  Inefficacy 23 (11.8 ± 4.5/16.8 ± 5.6) 28 (14.5 ± 5.3/18.8 ± 5.2) 51 (13.3 ± 5.1/17.9 ± 5.4)
Total 42 (10.9 ± 4.1/14.4 ± 5.9) 37 (13.5 ± 5.3/18.1 ± 5.6) 79 (12.1 ± 4.8/16.1 ± 6.0)
  1. The numbers in parentheses are the doses in the original methotrexate/re-employed methotrexate courses (mean ± standard deviation) in mg/week). The percentage of patients who were concordant for the presence or absence of inefficacy was 60.3% (P = 0.022, by McNemar test).