Figure 7From: Recent developments in our understanding of the renal basis of hyperuricemia and the development of novel antihyperuricemic therapeuticsMultiple sites of allopurinol action on pathways of purine and pyrimidine metabolism. Reactions inhibited by allopurinol are shown in red; reactions unaffected are shown in green. Allopurinol or its metabolites also result in depletion of intracellular 5-phosphoribosyl 1-pyrophosphate (PRPP) concentrations. AMP, adenosine monophosphate; CTP, cytosine triphosphate; GMP, guanosine monophosphate; HGPRT, hypoxanthine-guanine phosphoribosyltransferase; IMP, inosine monophosphate; OMPDC, orotidine-5'-monophosphate decarboxylase; OMP, orotidine monophosphate; OPRT, orotate phosphoribosyltransferase; PNP, purine nucleoside phosphorylase; PRPP, 5-phosphoribosyl 1-pyrophosphate; UMP, uridine monophosphate; UTP, uridine triphosphate; XOD, xanthine oxidase.Back to article page