Skip to main content

Volume 3 Supplement 2

21st European Workshop for Rheumatology Research

Temporal expression of cytokines and chemokines in rat adjuvant-induced arthritis

Adjuvant-induced arthritis (AIA) in rats is a relevant model for human rheumatoid arthritis (RA). In this study, th expression of the cytokines TNF-alpha, IL-1 and IL-6, as well as the chemokines MIP-1-alpha, MCP-1 and ENA-78 in the sera and joint homogenates of AIA and control, sham-injected rats was studied over a 47-day period. All of these cytokines and chemokines showed increased production in AIA. In addition, TNF-alpha, IL-1, ENA-78 and MIP-1-alpha could be termed as "early" mediators, as their production increased in the first 14-21 days and it correlated with early events in synovitis, such as neutrophil ingress, joint swelling and general symptoms. TNF-alpha may have mostly systemic, while IL-1 mainly local synovial effects. IL-6 and MCP-1 were found to be "late" inflammatory mediators, as their secretion was up-regulated after 2 weeks post-adjuvant injection and remained high during the observation period. Also, significant correlation was found between the production of TNF-alpha and that of chemokines. In conclusion, the differential expression of "early" and "late" cytokines and chemokines may account for various events underlying synovitis in AIA.

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Szekanecz, Z., Halloran, M., Woods, J. et al. Temporal expression of cytokines and chemokines in rat adjuvant-induced arthritis. Arthritis Res Ther 3, P024 (2001). https://doi.org/10.1186/ar193

Download citation

Keywords

  • Public Health
  • Rheumatoid Arthritis
  • Arthritis
  • Inflammatory Mediator
  • Early Event