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Table 2 The most attractive therapeutic targets for the development ofdisease-modifying osteoarthritis drugs

From: Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow

Target

Examples (where applicable)

Inflammatory process

Cytokines (IL-1β)

 

Nitric oxide and reactive oxygen species

 

Eicosanoids: leukotrienes and prostaglandins together

Ligand to PPARγ

 

Cartilage degradation

MMP-13 Aggrecanase-2 (ADAMTS-5)

Subchondral bone remodelling factors

 
  1. ADAMTS, a disintegrin and MMP domain with thrombospondin motifs; IL, interleukin; MMP, matrix metalloprotease; PPAR, peroxisome proliferator-activated receptor.
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Arthritis Research & Therapy

ISSN: 1478-6362

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