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Table 2 Genotype frequencies of PTPN22 1858 T/C SNP in RA patients, stratified by rheumatoid factor and anti-CCP antibody status

From: Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients

  CT CT and TT OR for CT and TT (95% CI)
RF+ (n = 291) 34.7 (101) 38.8 (113) 2.67a (1.88–3.79)
RF- (n = 99) 29.3 (29) 35.4 (35) 2.3a (1.42–3.72)
CCP+ (n = 193) 34.7 (67) 38.3 (74) 2.62a (1.78–3.86)
CCP- (n = 65) 35.4 (23) 38.5 (25) 2.63a (1.52–4.56)
  1. Values are the frequency in percent with absolute number of genotypes given in parentheses. Rheumatoid arthritis (RA) patients (n = 390) were stratified by rheumatoid factor (RF) status (values ≥40 IU/ml were regarded as RF positive (RF+)). RA patients for whom anti-cyclic citrullinated peptide (CCP) antibody concentrations were available (n = 258) were stratified according to anti-CCP positivity (values ≥50 IU/ml were regarded as CCP positive (CCP+)). The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated in the indicated patient subgroups in comparison to controls. Level of significance: ap = 0.001, power for all calculations α > 0.9.