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Table 2 IL-1F8 protein levels in mouse and human joint samples and in mouse skin

From: The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes

Samples Patients/animals IL-1F8 (pg/mg protein) IL-1β (pg/mg protein)
Human synovium OA (n = 4) 3.7 ± 1.4 3.6 ± 0.3
  Inflammatory arthritis (n = 5) 3.9 ± 1.0 11.6 ± 5.7a
Mouse joint Naïve (n = 1) 2.8 2.3
  Nonarthritic (n = 1) 2.7 4.5
  CIA earlyb (n = 3) 2.2 ± 0.3 16.6 ± 1.2c
  CIA lateb (n = 3) 4.5 ± 1.4 8.8 ± 0.8
Mouse skin Control (n = 3) 761.7 ± 313.4 16 ± 3
  PMA (n = 3) 14569.1 ± 3632.5d 28 ± 3d
  1. IL-1F8 protein levels were determined using enzyme-linked immunosorbent assay. aP < 0.05 versus osteoparthritis (OA), as assessed using the Mann-Whitney test. bCollagen-induced arthritis (CIA) early: days 1–7 after the onset of arthritis; CIA late: days 8–21 after onset of arthritis. cP < 0.05 versus late CIA, as assessed using analysis of variance. dP < 0.05 versus control, as assessed using analysis of variance.