Nuclear factor-κB essential modulator binding domain (NBD) peptide treatment significantly reduces bone destruction. (a) X-rays of the ankle joints (n = 10/group) were made, and radiological damage was scored. Representative pictures for NBD- and mutant NBD (MUT)-treated ankle joints are shown. Large arrow indicates ankle demineralization. Small arrow indicates midfoot demineralization and erosions. (b) NBD peptide treatment significantly reduces bone destruction. Data represent mean ± standard error of the mean (SEM) radiological scores (*p < 0.04). (c) No significant difference in bone destruction was observed in the contralateral, non-injected paws. Data represent mean ± SEM radiological scores.