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Table 3 Factors potentially affecting change in cartilage volume over 4.5 years

From: Knee cartilage loss in symptomatic knee osteoarthritis over 4.5 years

Factor Univariate analysis   Multivariate analysisa   
  Regression coefficient p Regression coefficient 95% CI p
Medial cartilage
   Initial ageb 1.6 0.84 3.7 - 10.9 to 18.2 0.62
   Genderc 28.3 0.08 12.6 - 29 to 54 0.55
   Heightd 1.11 0.20 - - -
   Weighte - 0.65 0.90 - - -
   Body mass indexf - 1.68 0.34 1.1 - 2.3 to 4.6 0.53
   Initial cartilage volumeg 41.2 0.15 18.3 - 19.4 to 56.1 0.34
   Bone sizeh 4.61 0.03 3.4 - 1.8 to 8.6 0.21
   WOMAC paini - 6.7 <0.001 - 7.1 - 10.8 to - 3.4 <0.001
Lateral cartilage
   Initial ageb 3.7 0.63 4.0 - 11.2 to 19.3 0.61
   Genderc 22.9 0.15 7.2 - 36.3 to 50.7 0.75
   Heightd 1.2 0.14 - - -
   Weighte 1.9 0.72 - - -
   Body mass indexf - 0.8 0.65 0.2 - 3.4 to 3.9 0.90
   Initial cartilage volumeg - 1.2 0.93 - 23.6 - 63.2 to 16.0 0.24
   Bone sizeh 3.6 0.07 2.9 - 2.6 to 8.4 0.29
   WOMAC paini - 1.6 0.40 - 1.7 - 5.5 to 2.2 0.40
  1. BMI, body mass index; CI, confidence interval; WOMAC, Western Ontario and McMaster University Osteoarthritis Index. aMultivariate analysis with age, gender, BMI, initial cartilage volume, bone size and initial pain (WOMAC) score in regression equation; bdifference in rate of loss of cartilage volume per 10-year difference in age; cdifference in rate of loss of cartilage volume for males compared with females; ddifference in rate of loss of cartilage volume per centimetre difference in height; edifference in rate of loss of cartilage volume per 10 kg difference in weight; fdifference in rate of loss of cartilage volume per unit increase in BMI; gdifference in rate of loss of cartilage volume per 1,000 mm3 increase in initial cartilage volume; hdifference in rate of loss of cartilage volume per 100 mm2 increase in bone area; idifference in rate of loss of cartilage volume per 10-unit increase in baseline WOMAC pain score.