Figure 1
From: Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts
Statins decrease the viability of synovial fibroblasts in a concentration-dependent manner. Synovial fibroblasts from a patient with rheumatoid arthritis were cultured for 96 hours in the presence of 1, 3 or 10 μM lovastatin, atorvastatin, simvastatin or cerivastatin. XTT assays were then performed on quadruplicate wells to determine the percentage cellular viability of statin-treated cultures in comparison with those treated with the vector. Results are representative of two experiments.