Inhibitory effect of ribbon-type NF-κB decoy oligodeoxynucleotides on osteoclast induction and activity in vitro and in vivo

Table 1 Mean histological scores and osteoclast numbers of rats with collagen-induced arthritis

Group	Number of joints	Histological score	Osteoclast number
PBS injection	5	3.0 ± 0.7	142.8 ± 15.1
RSODN injection	5	3.2 ± 0.8	153.8 ± 28.2
RNODN injection	5	1.8 ± 0.8^a	31.0 ± 37.3^b

^ap < 0.01 compared with PBS injection group; ^bp < 0.01 compared with PBS-injection group (n = 5 rats and n = 5 joints for each group). RNODN, ribbon-type NF-κB decoy oligodeoxynucleotide; RSODN, ribbon-type scrambled decoy oligodeoxynucleotide. Results are means ± SD.

ISSN: 1478-6362