Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis

Table 1 Identified arthritis-related gene clusters by transcriptome mapping

ID	Chr.	Position (Mb)	nof genes	* nof total genes	Included gene families
1	17	33	10	48	MHC class II
2	17	34	8	67	Complement
3	17	35	2	40	MHC class I
	17	33–35	20	155	MHC class II/Complement/MHC class I
4	11	81	3	10	CC chemokine ligand
5	11	82	5	25	Schlafen
6	11	83	3	23	CC chemokine ligand
	11	81–83	11	58	Schlafen/CC chemokine ligand
7	6	68	3	19	Immunoglobulin kappa chain
8	6	69	4	16	Immunoglobulin kappa chain
9	6	70	2	13	Immunoglobulin kappa chain
	6	68–70	9	48	Immunoglobulin kappa chain
10	12	112	4	8	Immunoglobulin heavy chain
11	12	113	2	3	Immunoglobulin heavy chain
	12	112–113	6	11	Immunoglobulin heavy chain
12	6	124	5	23	Complement/C-type lectin superfamily
13	15	79	5	27	Colony stimulating factor 2 receptor, beta
14	19	11	5	32	Membrane spanning four-domain, subfamily A
15	2	165	4	32	-
16	3	146	4	10	Guanylate nucleotide binding protein
17	17	17	4	11	Formyl peptide receptor
18	19	5	4	45	-
19	1	75	3	15	-
20	1	167	3	16	Selectin
21	1	174	3	20	(Fc receptor)
22	2	91	3	26	-
23	2	129	3	18	-
24	4	131	3	18	-
25	5	136	3	38	-
26	7	3	3	28	Paired-Ig-like receptor
27	7	37	3	46	-
28	7	39	3	29	Serum amyloid A
29	7	120	3	30	-
30	9	126	3	15	CC chemokine receptor
31	11	70	3	30	-
32	11	102	3	37	-
33	11	114	3	33	-
34	11	117	3	23	-
35	15	105	3	25	-
36	19	12	3	33	-
37	X	63	3	40	-

*Numbers of total genes in the corresponding 1 megabase were obtained from a Mouse Genome Search in The Bioinformatics Analytical Toolkit [20]. CC, Cysteine-Cysteine type; Chr., chromosome; Fc, Fragment crystallizable; ID, identification number; Ig, immunoglobulin; Mb, megabase; MHC, major histocompatibility complex.

ISSN: 1478-6362