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Table 2 Allelic and genotypic frequencies of KIR and HLA-B Bw4-I80 in patients with AS and B27 healthy controls in Spanish and Azorian populations.

From: Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations

Genotypes Spanish AS (2 n = 142) Spanish controls (2 n = 210) p OR (95%CI) Azorean AS (2 n = 110) Azorean controls (2 n = 114) p OR (95%CI)
3DS1 61 (42.9%) 47 (22.3%) <0.0001 2.6 (1.64–4.15) 39 (35.4%) 20 (17.5%) <0.003 2.58 (1.38–4.8)
3DL1 81 (57%) 163 (77.6%) <0.0001 0.3 (0.24–0.6) 71 (64.5%) 94 (82.4%) <0.003 0.38 (0.2–0.72)
Bw4I80 24 (16.9%) 40 (19%) NS - 18 (16.3%) 17 (14.9%) NS -
Genotypes Spanish AS ( n = 71) Spanish controls ( n = 105)    Azorean AS ( n = 55) Azorean controls ( n = 57)   
3DL1/3DL1 25 (35.2%) 65 (61.9%) 0.0008 0.33 (0.17–0.62) 20 (36.3%) 39 (68.4%) <0.001 0.26 (0.12–0.57)
3DS1/3DS1 15 (21.1%) 7 (6.6%) 0.0009 3.75 (1.44–9.74) 4 (7.2%) 2 (3.5%) NS -
3DS1/3DL1 31 (43.6%) 33 (31.4%) NS - 31 (56.1%) 16 (28%) 0.005 3.3 (1.50–7.26)
3DS1/Bw4I80 + 22 (30.9%) 16 (15.2%) 0.02 2.49 (1.2–5.19) 15 (27.2%) 5 (8.7%) 0.01 4.4 (1.48–13.37)
3DS1/Bw4I80 - 24 (33.8%) 24 (22.8%) NS - 20 (36.3%) 13 (22.8%) NS -
3DL1/Bw4I80 + 14 (19.7%) 37 (35.2%) 0.03 0.45 (0.22–0.91) 9 (16.3%) 16 (28%) NS -
3DL1/Bw4I80 - 42 (59.1%) 61 (58.1%) NS - 36 (64.4%) 39 (68.4%) NS -
  1. AS, ankylosing spondylitis; CI, confidence interval; HLA, human leukocyte antigen; KIR, killer cell immunoglobulin-like receptor; NS, not significant; OR, odds ratio.