Table 2 Allelic and genotypic frequencies of KIR and HLA-B Bw4-I80 in patients with AS and B27 healthy controls in Spanish and Azorian populations.
Genotypes | Spanish AS (2 n = 142) | Spanish controls (2 n = 210) | p | OR (95%CI) | Azorean AS (2 n = 110) | Azorean controls (2 n = 114) | p | OR (95%CI) |
|---|---|---|---|---|---|---|---|---|
3DS1 | 61 (42.9%) | 47 (22.3%) | <0.0001 | 2.6 (1.64–4.15) | 39 (35.4%) | 20 (17.5%) | <0.003 | 2.58 (1.38–4.8) |
3DL1 | 81 (57%) | 163 (77.6%) | <0.0001 | 0.3 (0.24–0.6) | 71 (64.5%) | 94 (82.4%) | <0.003 | 0.38 (0.2–0.72) |
Bw4I80 | 24 (16.9%) | 40 (19%) | NS | - | 18 (16.3%) | 17 (14.9%) | NS | - |
Genotypes | Spanish AS ( n = 71) | Spanish controls ( n = 105) | Azorean AS ( n = 55) | Azorean controls ( n = 57) | ||||
3DL1/3DL1 | 25 (35.2%) | 65 (61.9%) | 0.0008 | 0.33 (0.17–0.62) | 20 (36.3%) | 39 (68.4%) | <0.001 | 0.26 (0.12–0.57) |
3DS1/3DS1 | 15 (21.1%) | 7 (6.6%) | 0.0009 | 3.75 (1.44–9.74) | 4 (7.2%) | 2 (3.5%) | NS | - |
3DS1/3DL1 | 31 (43.6%) | 33 (31.4%) | NS | - | 31 (56.1%) | 16 (28%) | 0.005 | 3.3 (1.50–7.26) |
3DS1/Bw4I80 + | 22 (30.9%) | 16 (15.2%) | 0.02 | 2.49 (1.2–5.19) | 15 (27.2%) | 5 (8.7%) | 0.01 | 4.4 (1.48–13.37) |
3DS1/Bw4I80 - | 24 (33.8%) | 24 (22.8%) | NS | - | 20 (36.3%) | 13 (22.8%) | NS | - |
3DL1/Bw4I80 + | 14 (19.7%) | 37 (35.2%) | 0.03 | 0.45 (0.22–0.91) | 9 (16.3%) | 16 (28%) | NS | - |
3DL1/Bw4I80 - | 42 (59.1%) | 61 (58.1%) | NS | - | 36 (64.4%) | 39 (68.4%) | NS | - |