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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Differential expression, function and response to inflammatory stimuli of 11β-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation

Figure 4

Site-specific variations in human fibroblastic 11β-HSD1 expression versus other components of glucocorticoid metabolism and signalling. Expression of mRNA for (a) 11β-HSD1, (b) H6PDH, (c) GRα and (d) GRβ in bone marrow (B), and dermal (D) and synovial (S) fibroblasts in the presence or absence of TNF-α (10 ng/ml). For each gene product data were normalized for levels of the housekeeping gene 18S rRNA and are presented as fold change in expression relative to vehicle-treated bone marrow fibroblasts. *P < 0.01 versus vehicle control; #P < 0.01 versus equivalent bone marrow fibroblasts; &P < 0.01 versus equivalent dermal fibroblasts. 11β-HSD, 11β-hydroxysteroid dehydrogenase type 1; GR, glucocorticoid receptor; H6PDH, hexose-6-phosphate dehydrogenase; TNF, tumour necrosis factor.

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