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Table 3 Estimated pairwise haplotype frequencies in giant cell arteritis compared with healthy controls

From: Association of FCGR2A and FCGR2A-FCGR3Ahaplotypes with susceptibility to giant cell arteritis

Genes Haplotype Control GCA P value
FCGR2A-FCGR3A 131R-158F 0.360 0.502  
  131R-158V 0.135 0.078 0.07
  131H-158F 0.246 0.208  
  131H-158V 0.259 0.212  
FCGR3A-FCGR3B 158F-NA2 0.347 0.444  
  158F-NA1 0.272 0.268 0.16
  158V-NA2 0.339 0.225  
  158V-NA1 0.042 0.063  
FCGR3B-FCGR2B NA2-1206G 0.426 0.343  
  NA2-1206A 0.255 0.317 0.30
  NA1-1206G 0.255 0.311  
  NA1-1206A 0.064 0.029  
  1. Pairwise haplotypes produced from four biallelic markers (FCGR2A-131H/R, FCGR3A-158F/V, FCGR3B-NA2/1 and FCGR2B-1206G/A) denoted in the order they occur at the FCGR locus. Thus, 131R-158F indicates a haplotype containing FCGR2A-131R and FCGR3A-158F alleles. Empirical P values were obtained from a heterogeneity test statistic incorporated in the Permutation and Model-free analysis program after 1,000 permutations.