Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis

Table 3 Estimated pairwise haplotype frequencies in giant cell arteritis compared with healthy controls

Genes	Haplotype	Control	GCA	P value
FCGR2A-FCGR3A	131R-158F	0.360	0.502
	131R-158V	0.135	0.078	0.07
	131H-158F	0.246	0.208
	131H-158V	0.259	0.212
FCGR3A-FCGR3B	158F-NA2	0.347	0.444
	158F-NA1	0.272	0.268	0.16
	158V-NA2	0.339	0.225
	158V-NA1	0.042	0.063
FCGR3B-FCGR2B	NA2-1206G	0.426	0.343
	NA2-1206A	0.255	0.317	0.30
	NA1-1206G	0.255	0.311
	NA1-1206A	0.064	0.029

Pairwise haplotypes produced from four biallelic markers (FCGR2A-131H/R, FCGR3A-158F/V, FCGR3B-NA2/1 and FCGR2B-1206G/A) denoted in the order they occur at the FCGR locus. Thus, 131R-158F indicates a haplotype containing FCGR2A-131R and FCGR3A-158F alleles. Empirical P values were obtained from a heterogeneity test statistic incorporated in the Permutation and Model-free analysis program after 1,000 permutations.