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Table 2 The relative AMI risk associated with the use individual NSAIDs compared with remote or no use.

From: Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis

Drug [ref.] Relative AMI risk 95% CI Test for heterogeneity Test for inconsistency
    χ2 P value I2
Diclofenac 1.41 1.20–1.65 9.79 0.08 48.9%
   [27] 1.38 1.08–1.77    
   [16] 1.68 1.14–2.48    
   [19] 1.18 0.99–1.40    
   [6] 1.55 1.39–1.72    
   [18] 1.23 1.00–1.51    
Ibuprofen 1.11 1.04–1.18 8.26 0.41 3.2%
   [25] 1.15 1.03–1.29    
   [24] 1.01 0.77–1.33    
   [27] 1.17 0.87–1.58    
   [28] 1.02 0.88–1.18    
   [16] 0.74 0.35–1.56    
   [19] 1.06 0.87–1.29    
   [20] 1.06 0.96–1.17    
   [6] 1.24 1.11–1.39    
   [18] 1.16 0.92–1.46    
Naproxen 0.99 0.88–1.12 23.91 0.01 54%
   [25] 0.95 0.82–1.10    
   [24] 0.93 0.74–1.17    
   [27] 0.68 0.41–1.12    
   [28] 0.84 0.72–0.98    
   [16] 0.57 0.31–1.05    
   [23] 1.00 0.59–1.68    
   [19] 0.89 0.64–1.24    
   [20] 1.14 1.00–1.30    
   [6] 1.27 1.01–1.60    
   [21] 1.50 0.99–2.28    
   [22] 1.17 0.75–1.83    
   [18] 0.96 0.66–1.39    
  1. AMI, acute myocardial infarction; CI, confidence interval; NSAID, nonsteroidal anti-inflammatory drug.