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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Arthritis and Pain. Neurogenic origin of joint pain

Figure 1

Specimen recording from a knee joint afferent fibre during rotation (torque) of the knee. Close intra-arterial injection of a PAR4 agonist caused spontaneous nerve activity as well as increased afferent firing rate during normal rotation compared with control. This PAR4 sensitization of the nerve would be decoded as joint pain by the central nervous system. PAR, proteinase-activated receptor.

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Arthritis Research & Therapy

ISSN: 1478-6362

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