Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis

Table 1 Demographics and α-actinin binding in the various disease groups

Disease group	Female/male ratio (percentage)	Age in years (range)	OD α-actinin binding (range)	No. (percentage) with positive α-actinin binding
RA (n = 68)	65/35	67.7 (24 to 85)	0.102 (0.06 to 0.26)^a	8 (12)^a
SLE (n = 99)	92/8	35.7 (15 to 73)	0.112 (0.05 to 0.63)^a	20 (20)^a
WG (n = 85)	57/43	49.1 (17 to 76)	0.053 (0.04 to 0.08)	0 (0)
ANA-positive (n = 142)	63/37	52.2 (6 to 78)	0.09 (0.06 to 0.90)	46 (32)^a

^aIndicates significant difference compared with WG category. Numbers represent mean values (range) unless otherwise indicated. ANA, anti-nuclear antibody; OD, optical density; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; WG, Wegener's granulomatosis.

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