Table 4 Relative signal values of articular cartilage extracellular-matrix-related genes significantly affected by IL-1 and/or glucosamine
From: Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1β
Gene | Treatment group | |||
|---|---|---|---|---|
No glucosamine, no IL-1 | Glucosamine, no IL-1 | IL-1, no glucosamine | Glucosamine with IL-1 | |
A disintegrin and metalloproteinase domain 15 | 142.9 | 121.3 | 64.9 | 98.3 |
A disintegrin and metalloproteinase domain 17 | 434.6 | 533.1 | 897.4 | 616.6 |
ADAMTS-1 | 457.0 | 202.1 | 996.0 | 359.7 |
ADAMTS-4 | 79.2 | 149.8 | 76.0 | 149.4 |
Aggrecan-1 | 162.6 | 154.7 | 47.1 | 117.3 |
Biglycan | 80.9 | 26.1 | 126.8 | 19.2 |
Cartilage link protein | 662.1 | 284.3 | 75.9 | 166.7 |
Chondroitin sulfate proteoglycan 2 (Versican) | 135.3 | 45.3 | 418.1 | 60.0 |
Collagen type II alpha 1, chain precursor | 106.4 | 42.0 | 3.8 | 20.6 |
Collagen type III alpha 1 | 2710.2 | 2720.0 | 1320.4 | 2242.6 |
Collagen type VIII alpha 1 | 622.6 | 362.5 | 857.9 | 493.8 |
Collagen type XI alpha 1 | 2510.6 | 2090.9 | 1471.5 | 1830.9 |
Laminin α-4 chain precursor | 238.3 | 510.2 | 158.6 | 410.8 |
Matrix metalloproteinase 2 | 1014.0 | 1388.4 | 1825.7 | 1886.2 |
Matrix metalloproteinase 3 | 894.7 | 1966.4 | 5787.4 | 4223.6 |
Matrix metalloproteinase 9 | - | 11.1 | 2194.0 | 36.5 |
Matrix metalloproteinase 10 | - | 7.8 | 271.2 | 39.6 |
Matrix metalloproteinase 12 | 4.9 | 13.4 | 1132.0 | 84.9 |
Matrix metalloproteinase 13 | 268.3 | 2126.9 | 4497.4 | 3871.2 |
Syndecan 2 | 1515.8 | 1292.9 | 656.8 | 963.4 |
Syndecan 4 | 927.7 | 796.8 | 2049.2 | 1327.5 |
Thrombospondin 4 precursor | 2535.4 | 2217.7 | 1224.9 | 1662.6 |
TIMP-1 | 1786.8 | 1857.2 | 3049.8 | 2311.4 |
TIMP-2 | 995.9 | 937.0 | 726.9 | 923.1 |
TIMP-3 | 1317.1 | 1983.9 | 1105.3 | 1859.0 |