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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health

Figure 3

Relation of disease subtype and T-cell proliferative responses induced by aggrecan, fibrillin, and matrix metalloproteinase (MMP)-3. Proliferative responses to the aggrecan peptide of peripheral blood mononuclear cells (PBMC) from both oligoarticular and polyarticular juvenile idiopathic arthritis (JIA) patients differed significantly with those from healthy controls (p = 0.034 and p = 0.036, respectively). Only PBMC from patients with polyarticular JIA showed significant T-cell proliferative responses to the fibrillin peptide (p < 0.0001 versus healthy controls, p = 0.003 versus oligoarticular JIA). Positive proliferative responses to the MMP-3 peptide were seen in both JIA subgroups and healthy controls. Black bars: oligoarticular JIA; gray bars: polyarticular JIA; transparent bars: healthy controls. Asterisks indicate significant difference.

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Arthritis Research & Therapy

ISSN: 1478-6362

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