Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health

Table 2 Characteristics of the peptides derived from joint-related structures

Protein	Sequence	Position^a	Abbreviation
Aggrecan core protein precursor	LSGLPSGGEVLEISV	1,352–1,366	aggrecan
Aggrecan core protein precursor	ISGLPSGGDDLETST	924–938	aggrecan3
Calpain-2	HAYSVTGAEEVESNG	262–276	calpain
Fibrillin-1 precursor	CVDTRSGNCYLDIRP	1,526–1,540	fibrillin
Matrix metalloproteinase-1	GVVSHSFPATLETQE	14–28	MMP-1
Matrix metalloproteinase-3	FFYFFTGSSQLEFDP	446–460	MMP-3
Matrix metalloproteinase-10	SAFWPSLPSGLDAAY	329–343	MMP-10
Matrix metalloproteinase-16	VKEGHSPPDDVDIVI	539–553	MMP-16
Tenascin	EPVSGSFTTALDGPS	1,789–1,803	tenascin

^aAmino acid numbering according to the Swiss Protein Database. All peptides fulfill the computer search criteria described by van Bilsen and colleagues [25].

ISSN: 1478-6362