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Table 2 Characteristics of the peptides derived from joint-related structures

From: Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in health

Protein Sequence Positiona Abbreviation
Aggrecan core protein precursor LSGLPSGGEVLEISV 1,352–1,366 aggrecan
Aggrecan core protein precursor ISGLPSGGDDLETST 924–938 aggrecan3
Calpain-2 HAYSVTGAEEVESNG 262–276 calpain
Fibrillin-1 precursor CVDTRSGNCYLDIRP 1,526–1,540 fibrillin
Matrix metalloproteinase-1 GVVSHSFPATLETQE 14–28 MMP-1
Matrix metalloproteinase-3 FFYFFTGSSQLEFDP 446–460 MMP-3
Matrix metalloproteinase-10 SAFWPSLPSGLDAAY 329–343 MMP-10
Matrix metalloproteinase-16 VKEGHSPPDDVDIVI 539–553 MMP-16
Tenascin EPVSGSFTTALDGPS 1,789–1,803 tenascin
  1. aAmino acid numbering according to the Swiss Protein Database. All peptides fulfill the computer search criteria described by van Bilsen and colleagues [25].