The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

Table 2 Production of cytokines and matrix metalloproteinases

	Untreated		Anti-IL-1		Enbrel		Anti-IL-1 and Enbrel
	Mean	SEM	Mean	SEM	Mean	SEM	Mean	SEM
TNF (n = 7)	14.035	5.208	10.863	3.524	1.262	0.4787	1.291	0.5701
IL-1 (n = 7)	2.0587	1.216	0.00357	0.003858	0.767	0.310	0.002857	0.00291
IL-6 (n = 7)	1,218,830	374,998	735,202.7	180398.9	725,517	187,147.4	378,930.3	103,236.2
IL-8 (n = 7)	325.62	108.67	211.81	64.35	245.04	75.69	134.75	37.48
MCP-1 (n = 7)	62.29	15.43	60.29	16.17	51.58	13.95	41.56	11.65
MMP-1 (n = 7)	1,398.1	513.0	1,431.9	617.6	1,083.4	448.9	644.9	242.7
MMP-3 (n = 7)	4,508.7	1,840.7	4,920.8	2,197.1	3,953.4	1,789.2	3,169.7	1,543.6
MMP-9 (n = 6)	23.5	7.2	23.67	6.589	20.83	6.37	19.83	6.427
MMP-13 (n = 7)	3,772.3	1,428.5	4,262.7	1,312.1	2,730.5	715.4	1,644	538.2

IL, interleukin; MCP, monocyte chemoattractant protein; MMP, matrix metalloproteinase; SEM, standard error of the mean; TNF, tumour necrosis factor.

ISSN: 1478-6362