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Table 2 Production of cytokines and matrix metalloproteinases

From: The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

  Untreated Anti-IL-1 Enbrel Anti-IL-1 and Enbrel
  Mean SEM Mean SEM Mean SEM Mean SEM
TNF (n = 7) 14.035 5.208 10.863 3.524 1.262 0.4787 1.291 0.5701
IL-1 (n = 7) 2.0587 1.216 0.00357 0.003858 0.767 0.310 0.002857 0.00291
IL-6 (n = 7) 1,218,830 374,998 735,202.7 180398.9 725,517 187,147.4 378,930.3 103,236.2
IL-8 (n = 7) 325.62 108.67 211.81 64.35 245.04 75.69 134.75 37.48
MCP-1 (n = 7) 62.29 15.43 60.29 16.17 51.58 13.95 41.56 11.65
MMP-1 (n = 7) 1,398.1 513.0 1,431.9 617.6 1,083.4 448.9 644.9 242.7
MMP-3 (n = 7) 4,508.7 1,840.7 4,920.8 2,197.1 3,953.4 1,789.2 3,169.7 1,543.6
MMP-9 (n = 6) 23.5 7.2 23.67 6.589 20.83 6.37 19.83 6.427
MMP-13 (n = 7) 3,772.3 1,428.5 4,262.7 1,312.1 2,730.5 715.4 1,644 538.2
  1. IL, interleukin; MCP, monocyte chemoattractant protein; MMP, matrix metalloproteinase; SEM, standard error of the mean; TNF, tumour necrosis factor.