Table 1 Phenotype of mesenchymal stem and progenitor cells
Moleculea | Alternate names | Function/expression site | Reference |
|---|---|---|---|
Positive in MSCs | |||
   CD13 | Aminopeptidase N | Function unknown/granulocytes, monocytes, endothelial cells, BM stromal cells | [67,68] |
   CD29 | Integrin β1 | Leucocytes | [67] |
   CD44 | H-CAM, HUTCH-1, Hermes, Pgp-1 | Binds hyaluronic acid/most cell types | [8,69] |
   CD54 | ICAM-1 | Reacts with CD11a/CD18 or CD11b/CD18/activated T and B lymphocytes, activated endothelium |  |
   CD58 | LFA-3 |  | [38] |
   CD59 | Protectin | Inhibits membrane attack complex formation/all cells |  |
   CD61 | GPIIb/IIIa, β3 integrin chain | Plats, megas, macrophages | [68] |
   CD71 | Transferrin receptor | Mediates iron uptake/all proliferating cells | [67] |
   CD72 |  |  |  |
    CD73 | Ecto 5'-nucleotidase, recognized by SH3 and SH4 | Activation of B lymphocyte/T and B subpopulations | [8] |
    CD90 | Thy-1 | Unknown function/thymocytes, lymph node high endothelial venules, haematopoietic stem cells | [68] |
   CD102 | ICAM-2 | Lymphocyte trafficking and costimulation/lymphocyte populations, monocytes, endothelium |  |
    CD105 | Endoglin, recognized by SH2-antibody | TGF-β receptor, endothelial cells, syncythiotrophoblasts macrophages, connective tissue stromal cells, activated monocytes, BM subsets | [8] |
   CD106 | Vascular cell adhesion molecule-1 | Ligand for VLA-4 (α4β1 integrin) | [70] |
   CD109 | Platelet activating factor | Activated T cells, activated platelets, vascular endothelium | [68] |
   CD140b | PDGF receptor b |  | [71] |
   CD164 | MUC-24 | Endothelium, monocytes, BM stroma | [68] |
   CD166 | ALCAM (activated leukocyte cell adhesion molecule), recognized by antibody SB-10 | CD6 ligand/activated T cells, B lymphocytes, monocytes, thymic epithelium, fibroblasts, neurons | [72] |
   CD172a | SIRP alpha, N-CAM L1 | Tyrosine phophatase adhesion, transmembrane binds SH1 domain | [68] |
   MHC class-I |  | BM | [38,41] |
   STRO-1 | Recognized by STRO-1 mAb |  | [73] |
   BMP R1 |  | Bone morphogenetic protein receptor 1A |  |
   CD271 | LNGFR | Low affinity nerve growth factor receptor | [71] |
Negative in MSCs | |||
   CD3 | TCR associated | All T cells | [67] |
   CD11a | LFA-1 alpha | Integrin subunit/all leucocytes |  |
    CD14 | LPS-R | Receptor for endotoxin (lipopolysaccharide)/monocytes granulocytes, macrophages | [67,68] |
   CD15 | Lewis Ag | LPS binding | [67] |
   CD28 |  | Ligand for CD80 and CD86/T and B APC |  |
   CD31 |  | Binds CD38 | [67] |
   CD33 | Sialoadhesin | Myeloid progenitors, monocytes, macrophages, granulocyte lineage | [67] |
    CD34 |  | Ligand for CD 62L(L-selectin)/lymphohematopoietic stem and progenitor cells, small-vessel endothelial cells, embryonic fibroblasts | [67,68] |
   CD38 | Ayclic ADP-ribose hydrolase, NAD glycohydrolase | Augments B responses/plasma cells | [67] |
   CD40 | Bp50 | Growth, differentiation, and isotype-switching of B cells/B cells | [38] |
   CD40L | CD | Ligand for CD40/T cells |  |
    CD45 | Leucocyte common antigen | Critical for T and B cell antigen receptor mediated activation/all haematopoietic cells | [67,69,74] |
   CD80 | B7-1 | Ligand for CD28 and CD152 (CTLA-4), T-cell costimulation/B cells | [67,68,74] |
   CD86 | B7-2 | Ligand for CD28 and CD152 (CTLA-4)/B cells | [38] |
   CD117 | Stem cell factor receptor, c-KIT | Growth factor receptor/haemopoietic stem and progenitor cells, mast cells | [69] |
   CD133 | AC 133, hematopoietic stem cell antigen | Function unknown/haematopoietic stem cells and precursors |  |
   CD144 | Cadherin-5 |  |  |
   MHC class II |  |  | [41,67,69] |