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Figure 9 | Arthritis Research & Therapy

Figure 9

From: Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk

Figure 9

COX inhibition impairs reverse cholesterol transport. COX-1/2 inhibition downregulates 27-hydroxylase and ABCA1, thereby decreasing cholesterol efflux, in turn promoting the accumulation of cholesterol in macrophages that transform into foam cells. This effect is restored by the addition of prostaglandins. AA, arachidonic acid; ABCA1, ATP-binding cassette transporter A1; COX, cyclooxygenase; PG, prostaglandin; TXA, thromboxane A.

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Arthritis Research & Therapy

ISSN: 1478-6362

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